Pharmacogenomics: A Pharmacist's Guide to Tailored Therapy

Upon successful completion of this application-based CPE course, pharmacists should be able to:
1. Describe the pharmacists’ role in pharmacogenomics (PGx).
2. Discuss the state of PGx implementations across the industry.
3. Recognize basic mechanisms for genetic variation to impact medications.
4. Describe the standard nomenclature used in PGx.
5. Compare and contrast different types of genetic tests.
6. Provide specific examples that establish the relationship between altered drug disposition and genetic variants.
7. Describe how PGx can be utilized to predict an individual’s response to drug therapy.
8. Detail ethical, legal, and social issues (ELSI) and regulatory concerns surrounding PGx testing.
9. Review regulatory activity, especially FDA guidance and rulemaking, impacting PGx.
10. Describe the potential limitations of PGx testing.
11. Describe the role of various PGX resources available to support clinical application.
12. Discuss strategies to identify whether a drug-gene pair is ready for clinical use.
13. Recognize the value that PGx can bring to patient care.
14. Develop a pharmacotherapy regimen based on patient PGX results and characteristics.
15. Create PGx therapeutic guidelines for selected drugs using a specified framework.
16. Utilize clinical decision support tools to inform therapeutic recommendations.
17. Apply guidelines and other evidence to patient cases across multiple medical specialties and subspecialities (e.g., behavioral health, cardiology, oncology, pain management).
18. Identify the impact of ancestry on PGx variant frequencies.
19. Discuss the roles and responsibilities of clinical laboratories.
20. Describe criteria for selecting a PGx laboratory.
21. Compare and contrast provider-ordered clinical PGx lab testing vs direct-to-consumer genetic testing.
22. Detail the key components required in a PGx test for clinical practice.
23. Describe utilization of PGx in terms relevant for healthcare providers and payors.
24. Identify strategies to develop and deliver PGx recommendations to prescribers.
25. Explain genetic testing and its role in health care to patient.
26. Describe important counseling points for PGx testing.

1. Applying Pharmacogenomics to Patient Care – Our Current State
2. Genetics 101
3. Regulatory Review – Impact on Pharmacogenomics
4. Gene Information
5. Application to Practice – Opioids
6. From Phenotype to Drug Selection
7. Case-Based Application of Pharmacogenomics
8. Choosing a Laboratory Partner
9. Explaining Pharmacogenomic Results to Healthcare Providers
10. Explaining Pharmacogenomic Results to Patients