Statin-Related Side Effects: No Pain, No Gain…Nocebo?

Statin-Related Side Effects: No Pain, No Gain…Nocebo?

This month we are dissecting an article from the Journal of the American College of CardiologySide Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment.

The “nocebo effect” describes the negative outcome of a medication due to a belief that it will cause harm. This month’s Journal Club will discuss the SAMSON trial which evaluated the nocebo effect and its implications for approaching statin intolerance in patients.

Upon successful completion of this application-based course, participants should be able to:
1. Apply strategies to mitigate statin-related myalgias.
2. Define the ³nocebo effect” and identify clinical examples of this phenomenon.
3. Explain key findings from the SAMSON trial.
4. Discuss the strengths and limitations of the reviewed trial.
5. Discuss clinical implications of the trial and apply to a patient case.

Ariane Guthrie, PharmD, BCPS
PGY2 Geriatric Resident
Midwestern University College of Pharmacy – Glendale

Ariane Guthrie does not report any actual or potential conflicts of interest in relation to this continuing pharmacy education course. 

To obtain 1 contact hour of continuing pharmacy education credit (0.1 CEU), participants must read the article cited below, successfully pass the exam*, and complete the final course evaluation.
*CEimpact provides you with two (2) opportunities to complete the exam. If there are two failed attempts, the participant will not receive CPE credit.

ARTICLE: Howard JP, Wood FA, Finegold JA, et al. Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment. J Am Coll Cardiol. 2021 Sep 21;78(12):1210-1222. doi: 10.1016/j.jacc.2021.07.022. PMID: 34531021; PMCID: PMC8453640.

Course fee includes course, course materials, and CPE credit submission to CPE Monitor.
Course is non-refundable.
Initial Release Date: March 9, 2022
Planned Expiration Date: March 9, 2025

Copyright 2022, CEimpact. All Rights Reserved. Any reproduction of this course without express permission is strictly forbidden.  


Universal Activity Number (UAN): 0107-0000-22-055-H01-P
Application-based CPE Activity

CEImpact is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Obtain CPE credit by completing the course, followed by the exam and evaluation (if applicable). Once successfully completed, your course will appear in your Completed Courses tab. Access your CPE statement of credit at

¹CEImpact provides you with two (2) opportunities to complete the exam. The learner will not receive CPE credit after two failed attempts.

Additional information


1h 0m

Topic Designator

Disease State/Drug Therapy



ACPE Topic

01 Drug Therapy





Release Date






ACPE Number


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